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Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs
- Source :
- Polish journal of veterinary sciences. 20(3)
- Publication Year :
- 2017
-
Abstract
- This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m2. The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.
- Subjects :
- 0301 basic medicine
040301 veterinary sciences
Body Surface Area
Prednisolone
Pharmacology
Oral prednisolone
0403 veterinary science
03 medical and health sciences
Dogs
Pharmacokinetics
Medicine
Animals
Dosing
Glucocorticoids
Body surface area
General Veterinary
Dose-Response Relationship, Drug
business.industry
Body Weight
Area under the curve
food and beverages
04 agricultural and veterinary sciences
General Medicine
Breed
030104 developmental biology
Anesthesia
Area Under Curve
business
Weight based dosing
medicine.drug
Half-Life
Subjects
Details
- ISSN :
- 15051773
- Volume :
- 20
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Polish journal of veterinary sciences
- Accession number :
- edsair.doi.dedup.....b42b6a46ff5a25331df139dea3a05b87