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In vitroactivities of new and established triazoles against opportunistic filamentous and dimorphic fungi
- Source :
- Medical Mycology. 43:281-284
- Publication Year :
- 2005
- Publisher :
- Oxford University Press (OUP), 2005.
-
Abstract
- The in vitro activities of three new triazoles were determined and compared to those of itraconazole and fluconazole against 306 clinical isolates of Blastomyces dermatitidis, Cladophialophora carrionii, Coccidioides immitis, Fonsecaea pedrosoi, Fusarium spp., Histoplasma capsulatum, Paecilomyces lilacinus, Pseudallescheria boydii and Sporothrix schenckii. Minimum inhibitory concentrations (MIC) were determined by a broth macrodilution method of the National Committee for Clinical Laboratory Standards M38-A procedure. Itraconazole (geometric mean MIC, 0.16-0.65 microg/ml), voriconazole (geometric mean MIC, 0.18-1.44 microg/ml), ravuconazole (geometric mean MIC, 0.18-1.09 microg/ml), and posaconazole (geometric mean MIC, 0.18-1.38 microg/ml), had relatively uniform values showing potent in vitro inhibitory activity against B. dermatitidis, C. carrionii, C. immitis, F. pedrosoi, H. capsulatum, and S. schenckii. The in vitro activity was variable with strains of P. boydii, P. lilacinus and Fusarium spp.
- Subjects :
- Antifungal Agents
biology
Blastomyces dermatitidis
Coccidioides immitis
Fungi
Microbial Sensitivity Tests
General Medicine
Triazoles
bacterial infections and mycoses
Ravuconazole
biology.organism_classification
Microbiology
Pseudallescheria boydii
Fonsecaea pedrosoi
Thiazoles
Pyrimidines
Infectious Diseases
Mycoses
Species Specificity
Humans
Sporothrix schenckii
Voriconazole
Paecilomyces
skin and connective tissue diseases
Dimorphic fungus
Subjects
Details
- ISSN :
- 14602709 and 13693786
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Medical Mycology
- Accession number :
- edsair.doi.dedup.....b428d6cd097f5b915012114fa1e38850