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Identification of the General Anesthesia Induced Loss of Consciousness by Cross Fuzzy Entropy-Based Brain Network
- Source :
- IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 29
- Publication Year :
- 2021
-
Abstract
- Refereed/Peer-reviewed Although the spatiotemporal complexity and network connectivity are clarified to be disrupted during the general anesthesia (GA) induced unconsciousness, it remains to be difficult to exactly monitor the fluctuation of consciousness clinically. In this study, to track the loss of consciousness (LOC) induced by GA, we first developed the multi-channel cross fuzzy entropy method to construct the time-varying networks, whose temporal fluctuations were then explored and quantitatively evaluated. Thereafter, an algorithm was further proposed to detect the time onset at which patients lost their consciousness. The results clarified during the resting state, relatively stable fuzzy fluctuations in multi-channel network architectures and properties were found; by contrast, during the LOC period, the disrupted frontal-occipital connectivity occurred at the early stage, while at the later stage, the inner-frontal connectivity was identified. When specifically exploring the early LOC stage, the uphill of the clustering coefficients and the downhill of the characteristic path length were found, which might help resolve the propofol-induced consciousness fluctuation in patients. Moreover, the developed detection algorithm was validated to have great capacity in exactly capturing the time point (in seconds) at which patients lost consciousness. The findings demonstrated that the time-varying cross-fuzzy networks help decode the GA and are of great significance for developing anesthesia depth monitoring technology clinically.
- Subjects :
- Consciousness
Computer science
media_common.quotation_subject
Entropy
Biomedical Engineering
Unconsciousness
Electroencephalography
Anesthesia, General
Fuzzy logic
loss of consciousness
0903 Biomedical Engineering, 0906 Electrical and Electronic Engineering
Internal Medicine
medicine
Humans
Entropy (energy dispersal)
Time point
Cluster analysis
Propofol
media_common
Resting state fMRI
medicine.diagnostic_test
General Neuroscience
Rehabilitation
cross fuzzy entropy
Brain
general anesthesia
time-varying networks
Anesthesia
medicine.symptom
Subjects
Details
- ISSN :
- 15580210
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
- Accession number :
- edsair.doi.dedup.....b4275ae4bc3504a405aad01e511bef4f