Environmental oxygen affects ex vivo growth and proliferation of mesenchymal progenitors by modulating mitogen-activated protein kinase and mammalian target of rapamycin signaling

Stem and progenitor cells of hematopoietic and mesenchymal lineages reside in the bone marrow under low oxygen (OUsing cell-based assays and transcriptome and proteome data, the authors compared MSC cultures simultaneously grown under a conventional 19.95% OIn 5% OBased on the potential benefits for the growth and metabolism of MSCs, the authors propose the use of 5% O