Back to Search
Start Over
Electrophysiological correlates of visual backward masking in patients with first episode psychosis
-
Abstract
- Visual backward masking is strongly impaired in patients with schizophrenia. Masking deficits have been proposed as potential endophenotypes of schizophrenia. Masking performance deficits manifest as strongly reduced amplitudes in the electroencephalogram (EEG). In order to fulfill the criteria of an endophenotype, masking deficits should not vary substantially across time and should be present at the first psychotic event. To verify whether these conditions are met for visual backward masking, we tested patients with first episode psychosis (n = 21) in a longitudinal study. Patients were tested with visual backward masking and EEG three times every six months over a period of one year. We found that the EEG amplitudes of patients with first episode psychosis were higher as compared to those of patients with schizophrenia but lower as compared to those of unaffected controls. More interestingly, we found that the EEG amplitudes of patients with first episode psychosis remained stable over the course of one year. Since chronic schizophrenia patients have strongly reduced amplitudes, we speculate that the neural correlates of masking deficits (EEG amplitudes) continue to decrease as the disease progresses.
- Subjects :
- Masking (art)
Adult
Male
medicine.medical_specialty
Longitudinal study
Endophenotypes
Neuroscience (miscellaneous)
Audiology
Electroencephalography
03 medical and health sciences
Young Adult
0302 clinical medicine
Event-related potential
medicine
Humans
Radiology, Nuclear Medicine and imaging
Longitudinal Studies
Backward masking
Neural correlates of consciousness
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Psychotic Disorders
Schizophrenia
Endophenotype
Case-Control Studies
Visual Perception
Female
Schizophrenic Psychology
business
Perceptual Masking
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b40d43db5aa2d8b21d8ff044420eacf3