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Erythrocytosis in Spontaneously Hypertensive Rats
- Source :
- Journal of Clinical Investigation. 51:710-714
- Publication Year :
- 1972
- Publisher :
- American Society for Clinical Investigation, 1972.
-
Abstract
- During the study of an inbred strain of Wistar rats which spontaneously develop hypertension when they reach a weight of approximately 150 g, it was found that these animals also develop an erythrocytosis. A significant increase in red cell count was observed in spontaneously hypertensive (SH) rats (8-11 x 10(6) RBC/mm(3)) when compared with normotensive rats (6-7 x 10(6) RBC/mm(3)) of the same strain. This increase in red cell count paralleled the increase in body weight and the rise in blood pressure. Since the plasma volume, as measured with labeled albumin was normal, there was an absolute increase in red cells. The hematocrit and hemoglobin content of the blood measured in SH rats were only slightly greater than those found in normotensive rats. However, the mean cell volume (MCV) of the red cells in the SH rats was 45-47 mu(3) as compared with 51-53 mu(3) in normotensive rats.A fourfold increase in 24 hr (59)Fe incorporation into the red cells was found in the SH rats when compared with normotensive controls. The bone marrow of the SH rats showed erythroid hyperplasia. When the SH rats were treated with alpha-methyldopa (Aldomet 200 mg/kg daily, i.p.) the red cell count fell in parallel with the drop in blood pressure. No change in red cell count or blood pressure was observed in normotensive rats treated in the same manner. The erythropoietin titer was high in SH rats, and was undetectable in normotensive rats. These observations suggest a direct relationship between the hypertension and the erythrocytosis mediated by erythropoietin; both are genetically controlled.
- Subjects :
- Male
medicine.medical_specialty
Erythrocytes
Hypertension, Renal
Cell Survival
Iron
Blood Pressure
Polycythemia
Hematocrit
Hemoglobins
Leukocyte Count
Internal medicine
Chromium Isotopes
medicine
Animals
Plasma Volume
Serum Albumin, Radio-Iodinated
Erythropoietin
medicine.diagnostic_test
Red Cell
business.industry
Body Weight
Albumin
Blood Pressure Determination
Rats, Inbred Strains
Erythroid Hyperplasia
General Medicine
Iron Isotopes
Dihydroxyphenylalanine
Rats
Endocrinology
medicine.anatomical_structure
Blood pressure
Hypertension
Erythrocyte Count
Concise Publications
Female
Hemoglobin
Bone marrow
business
medicine.drug
Subjects
Details
- ISSN :
- 00219738
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....b40977233be570af1ab6479fa5734d76