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Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?
- Source :
- Nutrients; Volume 9; Issue 6; Pages: 633, Nutrients, Vol 9, Iss 6, p 633 (2017), Nutrients, Nutrients, Vol. 9, no.6, p. 633 [1-13] (2017)
- Publication Year :
- 2017
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2017.
-
Abstract
- Aging predisposes to hepatic dysfunction and inflammation that can contribute to the development of non-alcoholic fatty liver disease. Spirulina, a cyanobacterium used as a food additive or food supplement, has been shown to impact immune function. We have tested the potential hepatoprotective effect of a Spirulina in aged mice and to determine whether these effects can be related to a modulation of the gut microbiota. Old mice have been fed a standard diet supplemented with or without 5% Spirulina for six weeks. Among several changes of gut microbiota composition, an increase in Roseburia and Lactobacillus proportions occurs upon Spirulina treatment. Interestingly, parameters related to the innate immunity are upregulated in the small intestine of Spirulina-treated mice. Furthermore, the supplementation with Spirulina reduces several hepatic inflammatory and oxidative stress markers that are upregulated in old mice versus young mice. We conclude that the oral administration of a Spirulina is able to modulate the gut microbiota and to activate the immune system in the gut, a mechanism that may be involved in the improvement of the hepatic inflammation in aged mice. Those data open the way to new therapeutic tools in the management of immune alterations in aging, based on gut microbe-host interactions.
- Subjects :
- 0301 basic medicine
Male
Aging
Gut-liver axis
Pharmacology
Gut flora
Mice
Lactobacillus
2. Zero hunger
Spirulina (genus)
Nutrition and Dietetics
biology
Microbiota
Liver Diseases
Fatty liver
3. Good health
Up-Regulation
medicine.anatomical_structure
Spirulina
aging
microbiota
inflammaging
gut-liver axis
medicine.symptom
lcsh:Nutrition. Foods and food supply
Inflammation
lcsh:TX341-641
Article
Microbiology
03 medical and health sciences
Immune system
medicine
Animals
030109 nutrition & dietetics
Innate immune system
Bacteria
biology.organism_classification
medicine.disease
Inflammaging
Animal Feed
Small intestine
Immunity, Innate
Diet
Gastrointestinal Microbiome
Mice, Inbred C57BL
Oxidative Stress
030104 developmental biology
Gene Expression Regulation
Dietary Supplements
Biomarkers
Food Science
Antimicrobial Cationic Peptides
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients; Volume 9; Issue 6; Pages: 633
- Accession number :
- edsair.doi.dedup.....b40333b99278f8bc25500d1315ce5d84
- Full Text :
- https://doi.org/10.3390/nu9060633