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Juvenile Rhesus Monkeys Have Lower Type 2 Cytokine Responses than Adults after Primary Infection withSchistosoma mansoni
- Source :
- The Journal of Infectious Diseases. 187:939-945
- Publication Year :
- 2003
- Publisher :
- Oxford University Press (OUP), 2003.
-
Abstract
- Adults and children have differences in their susceptibility to schistosomiasis. The relative influences of age-dependent innate resistance and acquired immunity in the differences between susceptibility to schistosomiasis are difficult to assess in humans. Therefore, we exposed juvenile and adult female rhesus monkeys to primary infection with Schistosoma mansoni. In contrast to the adult animals, the juvenile rhesus monkeys had low levels of interleukin (IL)-4 and IL-5 production by peripheral blood mononuclear cells after schistosome infection, as well as lower levels of parasite-antigen-specific antibody (IgG, IgM, and IgA) responses, and produced limited antigen-specific or total IgE. Juvenile animals had statistically nonsignificant increased worm burdens and tissue or fecal egg counts, compared with that of adults, whereas circulating schistosome antigens were significantly higher in infected juvenile monkeys. These results suggest that juvenile rhesus monkeys have reduced type 2 cytokine responses after primary schistosome infections and perhaps are more susceptible to parasite infection.
- Subjects :
- Antibodies, Helminth
Schistosomiasis
Immunoglobulin E
Immune system
Species Specificity
medicine
Animals
Immunology and Allergy
Juvenile
Interleukin 5
Schistosoma
biology
Age Factors
Schistosoma mansoni
biology.organism_classification
medicine.disease
Macaca mulatta
Schistosomiasis mansoni
Disease Models, Animal
Infectious Diseases
Immunoglobulin M
Antigens, Helminth
Immunology
Leukocytes, Mononuclear
biology.protein
Cytokines
Female
Interleukin-4
Interleukin-5
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 187
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....b3feb0265e0b6bad01813f79bf8ca634
- Full Text :
- https://doi.org/10.1086/368130