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Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy
- Source :
- Clinical imaging. 33(4)
- Publication Year :
- 2008
-
Abstract
- Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
medicine.medical_treatment
Iron
Salvage therapy
Contrast Media
Adenocarcinoma
Sensitivity and Specificity
Prostate cancer
Ferumoxtran-10
Preoperative Care
medicine
Humans
Radiology, Nuclear Medicine and imaging
Magnetite Nanoparticles
Lymph node
Aged
Prostatectomy
Salvage Therapy
medicine.diagnostic_test
business.industry
Cancer
Prostatic Neoplasms
Reproducibility of Results
Magnetic resonance imaging
Dextrans
Oxides
medicine.disease
Image Enhancement
Magnetic Resonance Imaging
Ferrosoferric Oxide
Radiation therapy
medicine.anatomical_structure
Lymphatic Metastasis
Nanoparticles
Radiology
Lymph Nodes
Radiotherapy, Conformal
business
Subjects
Details
- ISSN :
- 18734499
- Volume :
- 33
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical imaging
- Accession number :
- edsair.doi.dedup.....b3f82f504b31ef7389164a62c8f88ef0