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Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis)
- Source :
- Journal of natural products. 67(12)
- Publication Year :
- 2004
-
Abstract
- The structure of a new prenylated coumarin (E-omega-benzoyloxyferulenol, 1b) from the Sardinian giant fennel (Ferula communis) has been confirmed by synthesis. The parent compound ferulenol (1a) showed sub-micromolar antimycobacterial activity, which was partly retained in 1b and in the simplified synthetic analogue 3, but diminished in its omega-hydroxy and omega-acetoxy derivatives (1c and 1d, respectively). The outstanding activity of 1a, its low toxicity, and the evidence for definite structure-activity relationships make this prenylated 4-hydroxycoumarin an interesting antibacterial chemotype worth further investigation.
- Subjects :
- Stereochemistry
medicine.drug_class
Pharmaceutical Science
Pharmacognosy
Antimycobacterial
Chemical synthesis
Analytical Chemistry
chemistry.chemical_compound
Structure-Activity Relationship
Coumarins
Drug Discovery
medicine
Ferula communis
Nuclear Magnetic Resonance, Biomolecular
Antibacterial agent
Pharmacology
chemistry.chemical_classification
Plants, Medicinal
Chemotype
biology
Molecular Structure
Chemistry
Organic Chemistry
Coumarin
biology.organism_classification
Anti-Bacterial Agents
Ferula
Complementary and alternative medicine
Italy
Molecular Medicine
Lactone
Subjects
Details
- ISSN :
- 01633864
- Volume :
- 67
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of natural products
- Accession number :
- edsair.doi.dedup.....b3f421761121cf09fa15ccc994892914