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Radionuclide ventriculography phase analysis for risk stratification of patients undergoing cardiotoxic cancer therapy
- Source :
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 29(2)
- Publication Year :
- 2020
-
Abstract
- Background Accurate diagnostic tools to identify patients at risk of cancer therapy-related cardiac dysfunction (CTRCD) are critical. For patients undergoing cardiotoxic cancer therapy, ejection fraction assessment using radionuclide ventriculography (RNVG) is commonly used for serial assessment of left ventricular (LV) function. Methods In this retrospective study, approximate entropy (ApEn), synchrony, entropy, and standard deviation from the phase histogram (phase SD) were investigated as potential early markers of LV dysfunction to predict CTRCD. These phase parameters were calculated from the baseline RNVG phase image for 177 breast cancer patients before commencing cardiotoxic therapy. Results Of the 177 patients, 11 had a decline in left ventricular ejection fraction (LVEF) of over 10% to an LVEF below 50% after treatment had commenced. This patient group had a significantly higher ApEn at baseline to those who maintained a normal LVEF throughout treatment. Of the parameters investigated, ApEn was superior for predicting the risk of CTRCD. Combining ApEn with the baseline LVEF further improved the discrimination between the groups. Conclusions The results suggest that RNVG phase analysis using approximate entropy may aid in the detection of sub-clinical LV contraction abnormalities, not detectable by baseline LVEF measurement, predicting a subsequent decline in LVEF.
- Subjects :
- medicine.medical_specialty
Heart Diseases
0206 medical engineering
Cancer therapy
Radionuclide ventriculography
Breast Neoplasms
02 engineering and technology
030204 cardiovascular system & hematology
Approximate entropy
Risk Assessment
Ventricular Function, Left
03 medical and health sciences
Ventricular Dysfunction, Left
0302 clinical medicine
Breast cancer
Internal medicine
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Radionuclide Ventriculography
Retrospective Studies
Ejection fraction
business.industry
Retrospective cohort study
Stroke Volume
medicine.disease
020601 biomedical engineering
Cardiotoxicity
Risk stratification
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Phase analysis
Subjects
Details
- ISSN :
- 15326551
- Volume :
- 29
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
- Accession number :
- edsair.doi.dedup.....b3ecbfbfadc1b145b022b435d871cd02