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Hormone replacement therapy trials: An update
- Source :
- Current Atherosclerosis Reports. 4:156-160
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- Recent randomized trials of hormone replacement therapy (HRT) in postmenopausal women are not consistent with the decrease in cardiovascular risk seen in observational studies of hormone therapy users compared with nonusers. Emerging evidence indicates that HRT use in some women with established coronary heart disease may be associated with prothrombotic effects or proinflammatory effects leading to adverse events. In healthy women, the decision to use HRT should be based primarily on non-cardiac factors until more data becomes available that is relevant to this population. Several alternatives to HRT, including phytoestrogens and selective estrogen receptor modulators, have favorable effects on cardiovascular risk factors, but their impact on clinical outcomes remains to be determined.
- Subjects :
- Selective Estrogen Receptor Modulators
Oncology
medicine.medical_specialty
medicine.medical_treatment
Population
Coronary Disease
Phytoestrogens
law.invention
Randomized controlled trial
law
Internal medicine
Humans
Medicine
Estrogens, Non-Steroidal
Adverse effect
education
Randomized Controlled Trials as Topic
education.field_of_study
business.industry
Estrogen Replacement Therapy
Middle Aged
Isoflavones
Postmenopause
Primary Prevention
Tamoxifen
Selective estrogen receptor modulator
Transgender hormone therapy
Raloxifene Hydrochloride
Physical therapy
Female
Observational study
Plant Preparations
Hormone therapy
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 15346242 and 15233804
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Current Atherosclerosis Reports
- Accession number :
- edsair.doi.dedup.....b3dfab50d0ca486e26cfc13c5707a484