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The epidemiological characteristics and molecular phylogeny of the dengue virus in Guangdong, China, 2015
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- In 2015, an unexpected multiple outbreak of dengue occurred in Guangdong, China. In total, 1,699 cases were reported, of which 1,627 cases were verified to have DENV infections by nucleic acid or NS1 protein, including 44 DENV-1, 1126 DENV-2, 18 DENV-3 and 6 DENV-4, and the other cases were confirmed by NS1 ELISA. Phylogenetic analyses of DENV-1 isolates identified two genotypes (I and V). The predominant DENV-2 outbreak isolates were the Cosmopolitan genotypes, which likely originated from Malaysia. The DENV-3 isolates were assigned into genotype I and genotype III. All 6 DENV-4 isolates from imported cases were likely originally from Cambodia, Thailand and the Philippines. The entomological surveillance showed a moderate risk for the BI index in Chaozhou and Foshan and a low risk in Guangzhou. The imported cases were mostly detected in Guangzhou and Foshan. Surprisingly, the most serious outbreak occurred in Chaozhou, but not in Guangzhou or Foshan. A combined analyses demonstrated the multiple geographical origins of this outbreak, and highlight the detection of suspected cases after the alerting of imported cases, early implementation of control policies and reinforce the vector surveillance strategies were the key points in the chain of prevention and control of dengue epidemics.
- Subjects :
- Adult
Male
0301 basic medicine
China
medicine.medical_specialty
Veterinary medicine
Adolescent
viruses
lcsh:Medicine
Mosquito Vectors
Dengue virus
Biology
medicine.disease_cause
Article
Disease Outbreaks
Dengue fever
Dengue
03 medical and health sciences
Aedes
Epidemiology
Genotype
medicine
Animals
Humans
Child
lcsh:Science
Phylogeny
Aged
Multidisciplinary
Phylogenetic tree
lcsh:R
Outbreak
virus diseases
Dengue Virus
Middle Aged
biochemical phenomena, metabolism, and nutrition
medicine.disease
030104 developmental biology
Child, Preschool
Molecular phylogenetics
Female
lcsh:Q
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....b3d6aa955f9f82c87c59d90b809773a5