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Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities
- Source :
- Natural Product Reports. 33:1146-1165
- Publication Year :
- 2016
- Publisher :
- Royal Society of Chemistry (RSC), 2016.
-
Abstract
- Covering: up to 2016 Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds.
- Subjects :
- 0301 basic medicine
Stereochemistry
Antimycin A
Structural diversity
Biology
01 natural sciences
Biochemistry
Chemical synthesis
03 medical and health sciences
chemistry.chemical_compound
Biosynthesis
Nonribosomal peptide
Depsipeptides
Drug Discovery
Actinomyces
Amino Acid Sequence
Peptide Synthases
Peptide sequence
chemistry.chemical_classification
Depsipeptide
Biological Products
Molecular Structure
ATP synthase
010405 organic chemistry
Organic Chemistry
0104 chemical sciences
030104 developmental biology
chemistry
biology.protein
Subjects
Details
- ISSN :
- 14604752 and 02650568
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Natural Product Reports
- Accession number :
- edsair.doi.dedup.....b3d5fa5c6934b05197dd1ad36fd839cd