Back to Search
Start Over
Exploitation of nanoparticle-protein interactions for early disease detection
- Publication Year :
- 2019
-
Abstract
- The main diagnostic tools for primary and metastatic central nervous system (CNS) tumors are the anamnestic neurological examination and the imaging tests, which are expensive and lack specificity. In recent years, the shell of macromolecules which forms on nanoparticles (NPs) when they are exposed to human blood, also known as hard corona (HC), became a powerful tool in diagnostics. Indeed, HC can act as a “nano-concentrator” of serum proteins and can detect minor changes in the protein concentration at the very early stages of disease development. In this paper, we characterized lipid NP HC formed in blood samples from patients affected by meningeal tumors. We found that the HCs of meningeal tumor patients could be discriminated from those of healthy subjects. Our results show that emerging HC-based technologies will pave the way for early diagnosis of CNS cancer.
- Subjects :
- 010302 applied physics
Pathology
medicine.medical_specialty
Physics and Astronomy (miscellaneous)
medicine.diagnostic_test
business.industry
Central nervous system
Early disease
Cancer
Neurological examination
02 engineering and technology
Disease
021001 nanoscience & nanotechnology
medicine.disease
Diagnostic tools
01 natural sciences
Blood proteins
Protein–protein interaction
medicine.anatomical_structure
0103 physical sciences
medicine
0210 nano-technology
business
biomolecular corona
nanoparticle
meningeal tumors
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b3bcf07299724696fd2d65fdcd0dcea6