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SARS‐CoV‐2 and Guillain–Barré syndrome: AIDP variant with a favourable outcome
- Source :
- European Journal of Neurology, European journal of neurology, vol. 27, no. 9, pp. 1751-1753
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The spectrum of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2), includes different neurologic manifestations of the central and peripheral nervous system. From March through April 2020, in two university hospitals located in western Switzerland, we examined three patients with Guillain-Barré syndrome (GBS) following SARS-CoV-2. These cases were characterized by a primary demyelinating electrophysiological pattern (Acute inflammatory demyelinating polyneuropathy or AIDP) and a less severe disease course compared to recently published case series. Clinical improvement was observed in all patients at week five. One patient was discharged from hospital after full recovery with persistence of minor neurological signs (areflexia). Two of the three patients remained hospitalized: one was able to walk and the other could stand up with assistance. We report three cases of typical GBS (AIDP) occurring after SARS-CoV-2 infection and presenting with a favourable clinical course. Given the interval between COVID-19-related symptoms and neurological manifestations (mean of 15 days) we postulate a secondary immune-mediated mechanism rather than direct viral damage.
- Subjects :
- medicine.medical_specialty
Guillain-Barre syndrome
Case Study
business.industry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
viruses
Clinical Neurology
Outbreak
Polyradiculoneuropathy
COVID-19/complications
Disease Progression
Female
Guillain-Barre Syndrome/drug therapy
Guillain-Barre Syndrome/etiology
Guillain-Barre Syndrome/physiopathology
Humans
Immunoglobulins, Intravenous/therapeutic use
Middle Aged
Neural Conduction/physiology
Switzerland
Treatment Outcome
COVID-19
electrodiagnostic testing
immune-mediated disorder
immunoglobulin therapy
infection
polyradiculoneuropathy
Disease
medicine.disease_cause
medicine.disease
Virus
03 medical and health sciences
0302 clinical medicine
Neurology
Internal medicine
medicine
030212 general & internal medicine
Neurology (clinical)
Respiratory system
business
030217 neurology & neurosurgery
Coronavirus
Subjects
Details
- Language :
- English
- ISSN :
- 14681331 and 13515101
- Database :
- OpenAIRE
- Journal :
- European Journal of Neurology
- Accession number :
- edsair.doi.dedup.....b3b65c0b9bc232779ee7caa43c44265c
- Full Text :
- https://doi.org/10.1111/ene.14368