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A Mixture of Ethanol Extracts of Persimmon Leaf and Citrus junos Sieb Improves Blood Coagulation Parameters and Ameliorates Lipid Metabolism Disturbances Caused by Diet-Induced Obesity in C57BL/6J Mice
- Source :
- Journal of Microbiology and Biotechnology. 26:295-308
- Publication Year :
- 2016
- Publisher :
- Journal of Microbiology and Biotechnology, 2016.
-
Abstract
- This study investigated the effects of a flavonoid-rich ethanol extract of persimmon leaf (PL), an ethanol extract of Citrus junos Sieb (CJS), and a PL-CJS mixture (MPC) on mice fed a highfat diet (HFD). We sought to elucidate the mechanisms of biological activity of these substances using measurements of blood coagulation indices and lipid metabolism parameters. C57BL/6J mice were fed a HFD with PL (0.5% (w/w)), CJS (0.1% (w/w)), or MPC (PL 0.5%, CJS 0.1% (w/w)) for 10 weeks. In comparison with data obtained for mice in the untreated HFD group, consumption of MPC remarkably prolonged the activated partial thromboplastin time (aPTT) and prothrombin time (PT), whereas exposure to PL prolonged aPTT only. Lower levels of plasma total cholesterol, hepatic cholesterol, and erythrocyte thiobarbituric acid-reactive substances, hepatic HMG-CoA reductase, and decreased SREBP-1c gene expression were observed in mice that received PL and MPC supplements compared with the respective values detected in the untreated HFD animals. Our results indicate that PL and MPC may have beneficial effects on blood circulation and lipid metabolism in obese mice.
- Subjects :
- Citrus
medicine.medical_specialty
Mice, Obese
030204 cardiovascular system & hematology
Diet, High-Fat
Applied Microbiology and Biotechnology
Thromboplastin
law.invention
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
law
Internal medicine
medicine
Animals
Obesity
Blood Coagulation
Triglycerides
Prothrombin time
Ethanol
medicine.diagnostic_test
Plant Extracts
Cholesterol
Anticholesteremic Agents
food and beverages
Lipid metabolism
General Medicine
Diospyros
Lipid Metabolism
Hydroxymethylglutaryl-CoA reductase
Mice, Inbred C57BL
Plant Leaves
Endocrinology
Liver
Biochemistry
chemistry
030220 oncology & carcinogenesis
Hydroxymethylglutaryl CoA Reductases
Prothrombin
Sterol Regulatory Element Binding Protein 1
Phytotherapy
Biotechnology
Partial thromboplastin time
Subjects
Details
- ISSN :
- 17388872 and 10177825
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Microbiology and Biotechnology
- Accession number :
- edsair.doi.dedup.....b3acb1583fe3d47e5d72d9b04434a53c