Hofmeister effect-enhanced gelatin/oxidized dextran hydrogels with improved mechanical properties and biocompatibility for wound healing

Compared with other types of hydrogels, natural derived hydrogels possess intrinsic advantages of degradability and biocompatibility. However, due to the low mechanical strength, their potential applications in biomedical areas are limited. In this study, Hofmeister effect-enhanced gelatin/oxidized dextran (Gel/O-Dex) hydrogels were designed with improved mechanical properties and biocompatibility to accelerate wound healing. Gel and O-Dex were chemically crosslinked through Schiff base reaction of aldehyde and amino groups. After soaking in kosmotrope solutions physical crosslinking domains were induced by Hofmeister effect including α-helix structures, hydrophobic interaction regions and helical junction zones among Gel molecular chains. The type of anions played different influence on the properties of hydrogels, which was consistent with the order of Hofmeister series. Particularly, H