Back to Search
Start Over
HIV-1 Viral protein-r (Vpr) protects against lethal superantigen challenge while maintaining homeostatic T cell levels in vivo
- Source :
- Molecular therapy : the journal of the American Society of Gene Therapy. 12(5)
- Publication Year :
- 2004
-
Abstract
- The HIV-1 accessory protein Vpr exhibits many interesting features related to macrophage and T cell biology. As a viral protein or as a soluble molecule it can suppress immune cell activation and cytokine production in vitro in part by targeted inhibition of NF-kappaB. In this regard we sought to test its effects in vivo on an NF-kappaB-dependent immune pathway. We examined the activity of Vpr in a lethal toxin-mediated challenge model in mice. Intravenous delivery of Vpr was sufficient to protect mice from lethal challenge with staphylococcal endotoxin B (SEB). Furthermore, Vpr protected host CD4+ T cells from in vivo depletion likely by preventing induction of AICD of SEB-exposed cells in a post-toxin-binding fashion. Understanding the biology of Vpr's activities in this model may allow for new insight into potential mechanisms of hyperinflammatory disease and into Vpr pathobiology in the context of HIV infection.
- Subjects :
- CD4-Positive T-Lymphocytes
Viral protein
viruses
medicine.medical_treatment
T cell
Staphylococcus
T-Lymphocytes
Biology
In Vitro Techniques
medicine.disease_cause
Lymphocyte Activation
chemistry.chemical_compound
Mice
Immune system
Drug Discovery
Genetics
medicine
Superantigen
Macrophage
Animals
Homeostasis
Lymphocyte Count
Molecular Biology
Pharmacology
Mice, Inbred BALB C
Gene Products, vpr
NF-kappa B
virus diseases
NF-κB
vpr Gene Products, Human Immunodeficiency Virus
biochemical phenomena, metabolism, and nutrition
In vitro
Endotoxins
Cytokine
medicine.anatomical_structure
chemistry
Liver
Immunology
HIV-1
Molecular Medicine
Cytokines
Female
Subjects
Details
- ISSN :
- 15250016
- Volume :
- 12
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Molecular therapy : the journal of the American Society of Gene Therapy
- Accession number :
- edsair.doi.dedup.....b38bae69f2e613e8c291903d1ff95da2