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Synthesis and Characterization of Ultralow Fouling Poly(N-acryloyl-glycinamide) Brushes
- Source :
- Langmuir. 33:13964-13972
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- The rational design of biomaterials with antifouling properties still remains a challenge, although this is important for many bench-to-bedside applications for biomedical implants, drug delivery carriers, and marine coatings. Herein, we synthesized and characterized poly(N-acryloylglycinamide) (polyNAGA) and then grafted poly(NAGA) onto Au substrate to form polymer brushes with well-controlled film stability, wettability, and thickness using surface-initiated atom transfer radical polymerization (SI-ATRP). The NAGA monomer integrates two hydrophilic amides on the side chain to enhance surface hydration, which is thought as a critical contributor to its antifouling property. The antifouling performances of poly(NAGA) brushes of different film thicknesses were then rigorously assessed and compared using protein adsorption assay from undiluted blood serum and plasma, cell-adhesive assay, and bacterial assay. The resulting poly(NAGA) brushes with a film thickness of 25-35 nm exhibited excellent in vitro antifouling ability to prevent unwanted protein adsorption (0.3 ng/cm
- Subjects :
- chemistry.chemical_classification
Materials science
Atom-transfer radical-polymerization
Substrate (chemistry)
02 engineering and technology
Surfaces and Interfaces
Polymer
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
01 natural sciences
0104 chemical sciences
Biofouling
chemistry.chemical_compound
Monomer
Blood serum
chemistry
Polymer chemistry
Electrochemistry
Side chain
General Materials Science
0210 nano-technology
Spectroscopy
Protein adsorption
Subjects
Details
- ISSN :
- 15205827 and 07437463
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Langmuir
- Accession number :
- edsair.doi.dedup.....b38b9cdd0fd2b319d43845e4a4fd830e