Back to Search
Start Over
Order and Disorder in the Replicative Complex of Paramyxoviruses
- Source :
- INTRINSICALLY DISORDERED PROTEINS STUDIED BY NMR SPECTROSCOPY, Felli, IC and Pierattelli, R. INTRINSICALLY DISORDERED PROTEINS STUDIED BY NMR SPECTROSCOPY, 870, pp.351-381, 2015, Advances in Experimental Medicine and Biology, 978-3-319-20164-1; 978-3-319-20163-4. ⟨10.1007/978-3-319-20164-1_12⟩, Advances in Experimental Medicine and Biology ISBN: 9783319201634
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- In this review we summarize available data showing the abundance of structural disorder within the nucleoprotein (N) and phosphoprotein (P) from three paramyxoviruses, namely the measles (MeV), Nipah (NiV) and Hendra (HeV) viruses. We provide a detailed description of the molecular mechanisms that govern the disorder-to-order transition that the intrinsically disordered C-terminal domain (NTAIL) of their N proteins undergoes upon binding to the C-terminal X domain (XD) of the homologous P proteins. We also show that a significant flexibility persists within NTAIL–XD complexes, which therefore provide illustrative examples of “fuzziness”. The functional implications of structural disorder for viral transcription and replication are discussed in light of the ability of disordered regions to establish a complex molecular partnership and to confer a considerable reach to the elements of the replicative machinery.
- Subjects :
- Genetics
0303 health sciences
biology
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]
viruses
Nipah virus
030302 biochemistry & molecular biology
biology.organism_classification
[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
3. Good health
Nucleoprotein
Measles virus
03 medical and health sciences
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Transcription (biology)
Phosphoprotein
Order and disorder
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Subjects
Details
- Language :
- English
- ISBN :
- 978-3-319-20164-1
978-3-319-20163-4 - ISBNs :
- 9783319201641 and 9783319201634
- Database :
- OpenAIRE
- Journal :
- INTRINSICALLY DISORDERED PROTEINS STUDIED BY NMR SPECTROSCOPY, Felli, IC and Pierattelli, R. INTRINSICALLY DISORDERED PROTEINS STUDIED BY NMR SPECTROSCOPY, 870, pp.351-381, 2015, Advances in Experimental Medicine and Biology, 978-3-319-20164-1; 978-3-319-20163-4. ⟨10.1007/978-3-319-20164-1_12⟩, Advances in Experimental Medicine and Biology ISBN: 9783319201634
- Accession number :
- edsair.doi.dedup.....b37743ce4e65c80d5da901ef721daee8