Back to Search
Start Over
Association Between c-Myc and Colorectal Cancer Prognosis: A Meta-Analysis
- Source :
- Frontiers in Physiology, Vol 9 (2018), Frontiers in Physiology
- Publication Year :
- 2018
- Publisher :
- Frontiers Media SA, 2018.
-
Abstract
- Background: There is debate as to whether c-Myc predicts prognosis in colorectal cancer (CRC). In this study, we aimed to review the association between c-Myc and CRC prognosis. Methods: Pertinent studies were identified by searching electronic databases and carefully reviewing the reference lists of pertinent studies until March 2016. The summary hazard ratio (HR) and corresponding 95% confidence interval (CI) were calculated to study the association between c-Myc and CRC prognosis. Results: Eight cohort studies (including seven studies about overall survival [OS] and one study about disease free survival [DFS]) were included. The pooled HR of OS was 1.13 (95% CI: 0.66–1.95). In subgroup analysis, no significant association between c-Myc and CRC prognosis was found in the studies either from Western countries (HR: 0.87, 95% CI: 0.68–1.10) or Asian countries (HR: 1.89, 95% CI: 0.62–5.77). HRs were 0.86 (95% CI: 0.38–1.94) and 1.57 (95% CI: 0.73–3.39) for the studies using univariate analysis and multivariate analysis, respectively. HR from the studies that examined DNA level was significantly different (HR: 2.05, 95% CI: 1.22–3.46); while that about RNA level or protein level was not significantly different. Conclusion: c-Myc was not associated with CRC prognosis in this meta-analysis. However, the conclusion is preliminary and should be examined in future studies.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Multivariate analysis
Physiology
Colorectal cancer
colorectal cancer
Subgroup analysis
lcsh:Physiology
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Internal medicine
medicine
Original Research
Univariate analysis
lcsh:QP1-981
business.industry
Hazard ratio
medicine.disease
Confidence interval
meta-analysis
c-Myc
030104 developmental biology
030220 oncology & carcinogenesis
Meta-analysis
biomarker
prognosis
business
Cohort study
Subjects
Details
- ISSN :
- 1664042X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physiology
- Accession number :
- edsair.doi.dedup.....b3713fe701a9700404bdcfde64b4e8cc