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Comparison of final heights of growth hormone-treated vs. untreated children with idiopathic growth failure
- Source :
- The Journal of clinical endocrinology and metabolism. 83(4)
- Publication Year :
- 1998
-
Abstract
- We measured adult heights (Ht) of 94 healthy GH-sufficient children (peak GH10 ng/mL, polyclonal RIA) whose Ht at presentation were more than 2 SD below the mean for chronological age, with normal weight-to-Ht ratios, normal body proportions, and pathologic growth velocity for chronological age. Group 1 (n 36, 6 females) received standardized doses (0.3 mg/kg x week) of GH (mean duration = 41 months), while group 2 (n = 58, 17 females) received no treatment. Our conclusion was that the mean final Ht SD score in the GH-treated group (-1.5) was significantly greater than in the untreated group (-2.1); P.001. Genetic predisposition to short stature was evident in both groups: the midparental Ht SD score was -1.1 in the treated and -1.0 in the untreated group. Midparental Ht was met or exceeded by 42% of the GH-treated group but only 15% of the untreated group. Final Ht was not significantly different from predicted Ht, except from GH-treated girls, who exceeded their predicted Ht. Although the mean Ht gains (6.8 cm in girls and 3 cm in boys) were modest and variable, GH treatment provided significantly better Ht outcomes for the majority of children with idiopathic growth failure.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Untreated group
Growth hormone
Biochemistry
Short stature
Growth velocity
Endocrinology
Internal medicine
Medicine
Humans
Child
Growth Disorders
Body proportions
business.industry
Human Growth Hormone
Biochemistry (medical)
Chronological age
Prognosis
Body Height
El Niño
Female
medicine.symptom
business
Hormone
Subjects
Details
- ISSN :
- 0021972X
- Volume :
- 83
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....b36600569d4bb95680ff2d90bd933945