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Recombinant Modified Vaccinia Ankara (MVA) effectively boosts DNA-primed HIV-specific immune responses in humans despite pre-existing vaccinia immunity
- Source :
- Vaccine. 27:4468-4474
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- The presence of vector-specific immune responses may hamper the induction of responses to a foreign antigen encoded by the vector. We evaluated the impact of pre-existing immunity to vaccinia virus on the induction of HIV-specific responses after immunization of healthy volunteers with a HIV-1 DNA prime-MVA boost vaccine. Following three priming immunizations with HIV-1 DNA plasmids, the volunteers were boosted with a single injection of recombinant MVA encoding HIV-1 proteins. Pre-existing immunity to vaccinia virus did not reduce the proportion of individuals who responded to HIV-1, but did lower the magnitude of responses. Our results suggest that vaccinia-based vectors can be used to efficiently induce immune responses to vectored HIV-1 antigens, even in individuals with pre-existing immunity to vaccinia virus.
- Subjects :
- Adult
Male
Modified vaccinia Ankara
HIV Antigens
animal diseases
viruses
Immunization, Secondary
HIV Infections
Vaccinia virus
chemical and pharmacologic phenomena
Antibodies, Viral
Article
Virus
Cell Line
DNA vaccination
Young Adult
chemistry.chemical_compound
Immune system
Neutralization Tests
Immunity
Chlorocebus aethiops
Vaccines, DNA
Animals
Humans
Poxviridae
Orthopoxvirus
AIDS Vaccines
Immunity, Cellular
Vaccines, Synthetic
General Veterinary
General Immunology and Microbiology
biology
Age Factors
Public Health, Environmental and Occupational Health
Middle Aged
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
Virology
Infectious Diseases
chemistry
Immunology
HIV-1
bacteria
Molecular Medicine
Female
Vaccinia
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....b35d7c2fc891ca48a4c8902247346745