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Profile of chromosomal aberrations in different gestational age spontaneous abortions detected by comparative genomic hybridization
- Source :
- European Journal of Obstetrics & Gynecology and Reproductive Biology. 131:127-131
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Objective To determine the frequency and type of chromosomal aberrations in different gestational age spontaneous abortions. Study design In the study, 106 spontaneous abortions (SAs) were studied by comparative genomic hybridization. Results The frequency of detected chromosomal aberrations was 37.7%. Numerical chromosomal aberrations were disclosed in 82.5% of the aberrant cases, while structural chromosomal aberrations-in 17.5%. Highest frequency of aberrations was detected in the blighted ovum specimens (62.5%) compared to missed and second trimester SAs (respectively, 36.0% and 34.8%). With regard to structural aberrations, the difference in the frequencies between blighted ovum specimens and second trimester SAs nearly reached statistical significance (p = 0.0847). However, due to the low number of blighted ovum specimens analyzed (n = 8), this result should be interpreted with due caution. The most frequently affected chromosomal arms were Xp and Xq (13.7% of aberrant chromosomal arms, each), followed by 16p (8.4%), 16q (8.4%), 15q (4.2%) and 19q (4.2%). Conclusions We describe for the first time a profile of chromosomal aberrations in SAs from different gestational ages, detected by CGH. Our results showed highest frequency of chromosome aberrations in blighted ovum specimens compared to other types of spontaneous abortions, higher rate of structural aberrations than reported before (17.5%) and some aberrations that so far were not found by CGH.
- Subjects :
- Adult
medicine.medical_specialty
Gestational Age
Biology
Monosomy
Pregnancy
Second trimester
medicine
Humans
Chromosome Aberrations
Gynecology
Chromosomes, Human, X
Developmental stage
Nucleic Acid Hybridization
Obstetrics and Gynecology
Gestational age
Chromosome
DNA
Aneuploidy
DNA Fingerprinting
Abortion, Spontaneous
Pregnancy Trimester, First
Reproductive Medicine
Pregnancy Trimester, Second
Female
Comparative genomic hybridization
Subjects
Details
- ISSN :
- 03012115
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Accession number :
- edsair.doi.dedup.....b354854b89b27c384ea6cf9b47a5daab