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Antipsychotic drugs and the risk of recurrent venous thromboembolism: A prospective cohort study
- Source :
- European journal of internal medicine. 52
- Publication Year :
- 2017
-
Abstract
- Background Numerous studies have suggested that antipsychotic drugs are associated with an increased risk for a first episode of venous thromboembolism (VTE). However, after anticoagulation discontinuation, the impact of antipsychotic drugs on the risk of recurrent VTE (rVTE) remains unknown. Objective To estimate the risk of rVTE in association with antipsychotic drugs. Methods Between May 2000 and December 2012, we included all consecutive patients with a first unprovoked symptomatic VTE and who discontinued anticoagulation. During follow-up, exposure to antipsychotic drugs was systematically assessed. Results A total of 736 patients with a first unprovoked symptomatic VTE were followed-up during a median period of 27.0 months (interquartile range (IQR) 6.2–60.0). Patients' median age was 66.0 years (IQR 49.0–76.0), 404 (54.9%) were men, and 61 (8.3%) were exposed to antipsychotics during follow-up. The incidence rate of r VTE was 12.1% person-year (95% CI 7.2–20.5) in antipsychotics users compared with 8.3% person-year (95% CI 7.1–9.8) in non-users (p = 0.20). Multivariate analysis showed a significant increased risk of recurrence associated with antipsychotic exposure (adjusted hazard ratio 1.9, 95% CI 1.1–3.3). Conclusions In this cohort study, exposure to antipsychotic drugs was found to be associated with an increased risk of rVTE among patients with a previous first unprovoked symptomatic VTE and who discontinued anticoagulation. Larger studies are needed to confirm and further explore this association.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
Drug Administration Schedule
03 medical and health sciences
0302 clinical medicine
Interquartile range
Recurrence
Risk Factors
Internal medicine
Internal Medicine
medicine
Humans
030212 general & internal medicine
Prospective Studies
Antipsychotic
Prospective cohort study
Aged
First episode
business.industry
Hazard ratio
Anticoagulants
Venous Thromboembolism
Middle Aged
medicine.disease
3. Good health
Pulmonary embolism
Discontinuation
Multivariate Analysis
Female
France
business
Cohort study
Antipsychotic Agents
Subjects
Details
- ISSN :
- 18790828
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- European journal of internal medicine
- Accession number :
- edsair.doi.dedup.....b34bb02da899d073e82912d55f616560