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Diagnosis of Intoxication by the Organophosphate VX: Comparison Between an Electrochemical Sensor and Ellman´s Photometric Method
- Source :
- Sensors (Basel, Switzerland), Sensors; Volume 8; Issue 9; Pages: 5229-5237, Sensors, Vol 8, Iss 9, Pp 5229-5237 (2008)
- Publication Year :
- 2008
- Publisher :
- Molecular Diversity Preservation International (MDPI), 2008.
-
Abstract
- An electrochemical sensor is introduced as a tool applicable for diagnosis of intoxication by cholinesterase inhibitors caused by the well-known nerve agent VX. The traditional Ellman method was chosen for comparison with the sensor's analytical parameters. Both methods are based on estimation of blood cholinesterase inhibition as a marker of intoxication. While Ellman´s method provided a limit of detection of 5.2´10-7 M for blood containing VX, the electrochemical sensor was able to detect 4.0´10-7 M. Good correlation between both methods was observed (R = 0.92). The electrochemical sensor could be considered a convenient tool for a fast yet accurate method, easily available for field as well as laboratory use. Time and cost savings are key features of the sensor-based assay.
- Subjects :
- diagnosis
Nanotechnology
lcsh:Chemical technology
biosensor
Biochemistry
Article
Analytical Chemistry
chemistry.chemical_compound
Organophosphate
intoxication
medicine
lcsh:TP1-1185
Electrical and Electronic Engineering
Instrumentation
Nerve agent
Detection limit
Chromatography
Chemistry
carbamate
Key features
Atomic and Molecular Physics, and Optics
Cholinesterase inhibition
Cost savings
Electrochemical gas sensor
Biosensor
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14248220
- Volume :
- 8
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Sensors (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....b34aae389ee9d0c8d0ab033d6f8a9f6b