Back to Search
Start Over
3D meshes of carbon nanotubes guide functional reconnection of segregated spinal explants
- Source :
- Science Advances
- Publication Year :
- 2016
-
Abstract
- Three-dimensional carbon nanotube frameworks favor spinal cord explant rewiring of motor outputs.<br />In modern neuroscience, significant progress in developing structural scaffolds integrated with the brain is provided by the increasing use of nanomaterials. We show that a multiwalled carbon nanotube self-standing framework, consisting of a three-dimensional (3D) mesh of interconnected, conductive, pure carbon nanotubes, can guide the formation of neural webs in vitro where the spontaneous regrowth of neurite bundles is molded into a dense random net. This morphology of the fiber regrowth shaped by the 3D structure supports the successful reconnection of segregated spinal cord segments. We further observed in vivo the adaptability of these 3D devices in a healthy physiological environment. Our study shows that 3D artificial scaffolds may drive local rewiring in vitro and hold great potential for the development of future in vivo interfaces.
- Subjects :
- Male
Physics::Medical Physics
Cell Culture Techniques
Biocompatible Materials
02 engineering and technology
Computer Science::Human-Computer Interaction
Settore BIO/09 - Fisiologia
Nanomaterials
law.invention
Mice
0302 clinical medicine
Tissue engineering
Carbon nanotubes sponges
law
neural interfaces
Fiber
Research Articles
Visual Cortex
Multidisciplinary
Microscopy, Confocal
Tissue Scaffolds
SciAdv r-articles
021001 nanoscience & nanotechnology
Nanomaterial
microscopy
0210 nano-technology
Research Article
Nanotube
Materials science
Neurite
Quantitative Biology::Tissues and Organs
organotypic cultures
Nanotechnology
Carbon nanotube
Multiwalled carbon
Settore FIS/03 - Fisica della Materia
Quantitative Biology::Subcellular Processes
03 medical and health sciences
tissue engineering
spinal cord
Animals
Polygon mesh
Rats, Wistar
carbon nanotube
Quantitative Biology::Neurons and Cognition
Tissue Engineering
carbon nanotubes
Nanotubes, Carbon
nanomaterials
Electric Stimulation
Electrophysiological Phenomena
Rats
Mice, Inbred C57BL
Settore M-PSI/02 - Psicobiologia e Psicologia Fisiologica
organotypic culture
Microscopy, Electron, Scanning
Nanoparticles
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Science Advances
- Accession number :
- edsair.doi.dedup.....b340969bfd34606983faecdd1ea02ba6