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Increased Levels of Neutrophil-Activating Peptide-2 in Acute Coronary Syndromes
- Source :
- Journal of the American College of Cardiology. 48(8):1591-1599
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- OBJECTIVES We sought to investigate the role of the CXC chemokine neutrophil-activating peptide-2 (NAP-2) in atherogenesis and plaque destabilization. BACKGROUND Chemokines are involved in atherogenesis, but the role of NAP-2 in atherosclerotic disorders is unclear. Based on its potential pro-atherogenic properties, we hypothesized a pathogenic role for NAP-2 in coronary artery disease. METHODS We tested this hypothesis by differential experimental approaches including studies in patients with stable (n = 40) and unstable angina (n = 40) and healthy control subjects (n = 20). RESULTS The following results were discovered: 1) patients with stable, and particularly those with unstable, angina had markedly raised plasma levels of NAP-2 compared with control subjects, accompanied by increased expression of CXC receptor 2 in monocytes; 2) platelets, but also peripheral blood mononuclear cells (PBMCs), released large amounts of NAP-2 upon stimulation, with a particularly prominent PBMC response in unstable angina; 3) NAP-2 protein was detected in macrophages and smooth muscle cells of atherosclerotic plaques and in monocytes and platelets of coronary thrombi; 4) in vitro, recombinant and platelet-derived NAP-2 increased the expression of adhesion molecules and chemokines in endothelial cells; and 5) whereas aspirin reduced plasma levels of NAP-2, statin therapy increased NAP-2 with stimulating effects both on platelets and leukocytes. CONCLUSIONS Our findings suggest that NAP-2 has the potential to induce inflammatory responses within the atherosclerotic plaque. By its ability to promote leukocyte and endothelial cell activation, such a NAP-2-driven inflammation could promote plaque rupture and acute coronary syndromes.
- Subjects :
- Chemokine
biology
Unstable angina
business.industry
musculoskeletal, neural, and ocular physiology
fungi
Inflammation
medicine.disease
Peripheral blood mononuclear cell
Endothelial stem cell
Angina
Coronary artery disease
mental disorders
Immunology
biology.protein
medicine
Platelet
medicine.symptom
business
Cardiology and Cardiovascular Medicine
psychological phenomena and processes
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 48
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....b32573ca220e1d1ea70d326bd041da55
- Full Text :
- https://doi.org/10.1016/j.jacc.2006.06.060