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Stimulation of Human Melanocytes by Vitamin D3 Possibly Mediates Skin Pigmentation After Sun Exposure
- Source :
- Journal of Investigative Dermatology. 90:882-884
- Publication Year :
- 1988
- Publisher :
- Elsevier BV, 1988.
-
Abstract
- We found an increased amount of immunoreactive tyrosinase in human melanocytes after 6-d culturing with vitamin D3 (cholecalciferol). Most of these melanocytes became more dendritic and swollen in a fashion similar to that noted in the skin after ultraviolet irradiation. However, 7-dehydrocholesterol (pro-vitamin D3) or 1 alpha,25-dihydroxy-vitamin D3 (activated vitamin D3) were found to have little effect on the same system. Because vitamin D3 is known to be photochemically converted from pro-vitamin D3 in the skin by ultraviolet irradiation, the mechanism of human skin pigmentation after ultraviolet irradiation, thus far unknown, may be at least partly explained by this stimulating effect of vitamin D3 on melanocytes.
- Subjects :
- Male
Vitamin
medicine.medical_specialty
Ultraviolet Rays
Tyrosinase
Skin Pigmentation
Human skin
Stimulation
Dermatology
Melanocyte
Biochemistry
chemistry.chemical_compound
Internal medicine
medicine
Humans
Molecular Biology
Cholecalciferol
Monophenol Monooxygenase
Cell Biology
Endocrinology
medicine.anatomical_structure
chemistry
Cell culture
Melanocytes
Fetal bovine serum
Subjects
Details
- ISSN :
- 0022202X
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology
- Accession number :
- edsair.doi.dedup.....b321da3f173d7d45c3ec602404965c02