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Total serum immunoglobulin M levels are affected by immunomodulators in seabream (Sparus aurata L.)
- Source :
- Veterinary immunology and immunopathology. 101(3-4)
- Publication Year :
- 2003
-
Abstract
- Immunoglobulin M (IgM) is a major component of the teleost humoral immune system. Despite the significance of IgM levels as an immune parameter, there are relatively few studies on changes induced in its total levels in serum. This study examines the effects of several immunomodulators (vitamin A, chitin, yeast cells or levamisole, which act as immunostimulants, and crowding, hypoxia or anaesthetics, which act as stressors) upon the total serum IgM levels of non-immunized gilthead seabream (Sparus aurata L.). Total serum IgM levels of fish fed with the assayed immunostimulant-supplemented diets were statistically higher than those in fish fed a non-supplemented diet, especially in the case of levamisole. On the other hand, serum IgM levels of fish subjected to different stressors were not affected by crowding, hypoxia or certain anaesthetics. However, benzocaine and a narcotic dose of 2-phenoxyethanol provoked a great reduction, while quinaldine sulphate increased IgM levels to a significant degree. These results show how the seric IgM levels can be differently affected by some immunomodulators and the important role they may play in the regulation of total circulating IgM levels in seabream. The possibility of using total serum IgM for assessing immunostimulation, disease diagnosis and stress symptoms during fish farming is discussed.
- Subjects :
- Vitamin
medicine.medical_specialty
Increased IgM level
Fish farming
Immunology
Chitin
Enzyme-Linked Immunosorbent Assay
Aquaculture
Saccharomyces cerevisiae
Biology
chemistry.chemical_compound
Random Allocation
Immune system
Adjuvants, Immunologic
Stress, Physiological
Internal medicine
medicine
Animals
Hypoxia
Vitamin A
General Veterinary
business.industry
Levamisole
Hypoxia (medical)
Sea Bream
Endocrinology
Crowding
chemistry
Immunoglobulin M
biology.protein
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 01652427
- Volume :
- 101
- Issue :
- 3-4
- Database :
- OpenAIRE
- Journal :
- Veterinary immunology and immunopathology
- Accession number :
- edsair.doi.dedup.....b31c5c18f82468b5d499c7e8e7232ea8