Back to Search
Start Over
Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria
- Source :
- The Journal of Infectious Diseases. 215:S9-S17
- Publication Year :
- 2017
- Publisher :
- Oxford University Press (OUP), 2017.
-
Abstract
- Diseases caused by antibiotic-resistant bacteria in hospitals are the outcome of complex relationships between several dynamic factors, including bacterial pathogenicity, the fitness costs of resistance in the human host, and selective forces resulting from interventions such as antibiotic therapy. The emergence and fate of mutations that drive antibiotic resistance are governed by these interactions. In this review, we will examine how different forms of antibiotic resistance modulate bacterial fitness and virulence potential, thus influencing the ability of pathogens to evolve in the context of nosocomial infections. We will focus on 3 important multidrug-resistant pathogens that are notoriously problematic in hospitals: Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus. An understanding of how antibiotic resistance mutations shape the pathobiology of multidrug-resistant infections has the potential to drive novel strategies that can control the development and spread of drug resistance.
- Subjects :
- Acinetobacter baumannii
0301 basic medicine
Staphylococcus aureus
Virulence Factors
030106 microbiology
Porins
Virulence
Context (language use)
Microbial Sensitivity Tests
Drug resistance
Biology
medicine.disease_cause
beta-Lactam Resistance
beta-Lactamases
Microbiology
Bacterial genetics
03 medical and health sciences
Antibiotic resistance
Bacterial Proteins
Drug Resistance, Multiple, Bacterial
medicine
Animals
Humans
Immunology and Allergy
Pseudomonas Infections
Cross Infection
Pseudomonas aeruginosa
Gene Expression Regulation, Bacterial
Staphylococcal Infections
biology.organism_classification
Anti-Bacterial Agents
Infectious Diseases
Mutation
Supplement Article
Bacteria
Acinetobacter Infections
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 215
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....b30f058f67834ef35d72879f6d05b2a5