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The Lactobacillus brevis 47 f Strain Protects the Murine Intestine from Enteropathy Induced by 5-Fluorouracil
- Source :
- Microorganisms, Volume 8, Issue 6, Microorganisms, Vol 8, Iss 876, p 876 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- We report that the results of our study indicate that Lactobacillus brevis 47 f strain isolated from the faeces of a healthy individual prevents the manifestations of experimental mucositis induced by treatment of Balb/c mice with the anticancer drug 5-fluorouracil (5 FU<br />100 mg/kg i.p. &times<br />3 days). The presence of damage to the intestine and the colon was determined by a morphometric analysis of specimens including the height of villi, the amount of goblet cells and infiltrating mononuclear cells, and the expression of the proliferative Ki-67 antigen. Changes in the lipid peroxidation in the blood and the intestine were determined by severalfold increase of the concentration of malonic dialdehyde. Oral administration of L.brevis 47 f strain prior to 5 FU decreased the drug-induced morphological and biochemical changes to their respective physiological levels<br />the ability of intestinal epitheliocytes to express Ki-67 was partially restored. These effects of L.brevis 47 f strain were more pronounced or similar to those of the reference compound Rebamipid, a quinoline derivative known to protect the gut from drug-induced toxicity. Thus, the new lactobacilli strain attenuates the severity of 5 FU-induced enteropathy.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Microbiology
Peripheral blood mononuclear cell
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Antigen
Virology
Lactobacillus
medicine
oxidative stress
Enteropathy
5-fluorouracil
lcsh:QH301-705.5
biology
Strain (chemistry)
Chemistry
Lactobacillus brevis
biology.organism_classification
medicine.disease
Molecular biology
lactobacillus
030104 developmental biology
mucositis
antioxidants
lcsh:Biology (General)
030220 oncology & carcinogenesis
Toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 20762607
- Database :
- OpenAIRE
- Journal :
- Microorganisms
- Accession number :
- edsair.doi.dedup.....b30330975e9c1fb04a4ad60e69428cd8
- Full Text :
- https://doi.org/10.3390/microorganisms8060876