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Rare Mixed Adenoneuroendocrine Carcinoma of the Gallbladder: Case Report and Review of Literature
- Source :
- The American Journal of Case Reports
- Publication Year :
- 2021
-
Abstract
- Patient: Female, 58-year-old Final Diagnosis: Mixed adenoneuroendocrine carcinoma of the gallbladder Symptoms: Abdominal pain • asthenia Medication: — Clinical Procedure: — Specialty: Surgery Objective: Rare disease Background: Mixed adenoneuroendocrine carcinoma of the gallbladder (gMANEC) is an extremely rare cancer. Most of the cases are reported in Asia, North America, and Europe, with no cases reported in Latin America; this is the first report for this region, and the 24th case reported worldwide. Case Report: A 68-year-old woman was referred to our department due to asthenia and moderate abdominal pain in the right upper quadrant for 6 months, with imaging examinations showing a solid heterogeneous expansive lesion in gallbladder topography and segment IV of the liver. The MRI displayed an expansive and heterogeneous lesion with inaccurate limits in the gallbladder affecting segment IVb of the liver, in addition to lymphadenopathy in the hepatic hilum. A cholecystectomy with resection of segments IV-B and V of the liver (radical cholecystectomy) and hepatic hilar lymphadenectomy were performed. Anatomopathological examination and immunohisto-chemistry confirmed a primary mixed adenoneuroendocrine carcinoma of the gallbladder. The patient received adjuvant chemotherapy and radiotherapy; however, after the patient reported experiencing low back pain, a CT was performed, revealing retroperitoneal metastasis, and the radiotherapy was interrupted. Currently, the patient has a stable disease, following a protocol of 5-Fluorouracil and somatostatin, and she reports having low back pain of low intensity. Conclusions: This is the 24th gMANEC case reported in the literature. The tumor was successfully resected; however, the patient presented retroperitoneal metastasis 6 months after surgery, despite combined adjuvant therapy.
- Subjects :
- Abdominal pain
medicine.medical_specialty
medicine.medical_treatment
030204 cardiovascular system & hematology
Adenocarcinoma
03 medical and health sciences
0302 clinical medicine
medicine
Adjuvant therapy
Carcinoma
Humans
Cholecystectomy
Aged
Mixed tumor
business.industry
Gallbladder
General Medicine
Articles
medicine.disease
Neuroendocrine Tumors
medicine.anatomical_structure
Mixed Tumor, Malignant
030220 oncology & carcinogenesis
Lymph Node Excision
Lymphadenectomy
Female
Gallbladder Neoplasms
Radiology
Gallbladder Neoplasm
medicine.symptom
business
Subjects
Details
- ISSN :
- 19415923
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- The American journal of case reports
- Accession number :
- edsair.doi.dedup.....b2e4a36dd3015100c55c9fa702e33caf