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Whole body positron emission tomography in follow-up of high risk melanoma
- Source :
- Acta oncologica (Stockholm, Sweden). 46(5)
- Publication Year :
- 2007
-
Abstract
- The aim of this study was to determine the clinical impact of whole body positron emission tomography (FDG PET) to detect clinically silent metastases in the follow-up of patients with high risk melanoma. FDG PET was performed to 30 asymptomatic melanoma patients (AJCC stage IIB-IIIC) 7-24 months after the primary surgery and sentinel node biopsy. FDG PET was able to detect six of seven recurrences, constituting 20% of all study patients. One patient presented with a negative FDG PET finding at the very first scanning, but was positive later in a repeated scan after manifestation of palpable mass in the axilla. The positive PET finding had an impact on treatment decisions in every case: three patients underwent surgical resection and four patients received chemotherapy or interferon. The mean follow-up time was 27 months (range, 12-48 months) and during that time the other 23 patients with true negative FDG PET were disease-free. One of the seven recurrences was in remission after surgical metastasectomy. In conclusion, whole body FDG PET is a valuable follow-up tool in high risk melanoma to diagnose recurrences and to select the patients, who are suitable for surgical metastasectomy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Skin Neoplasms
medicine.medical_treatment
Asymptomatic
Fluorodeoxyglucose F18
Biopsy
medicine
Humans
Radiology, Nuclear Medicine and imaging
Whole Body Imaging
Melanoma
Aged
Aged, 80 and over
Chemotherapy
medicine.diagnostic_test
business.industry
Hematology
General Medicine
Sentinel node
Middle Aged
medicine.disease
Axilla
medicine.anatomical_structure
Oncology
Positron emission tomography
Positron-Emission Tomography
Female
Radiology
Metastasectomy
medicine.symptom
Radiopharmaceuticals
Nuclear medicine
business
Subjects
Details
- ISSN :
- 0284186X
- Volume :
- 46
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Acta oncologica (Stockholm, Sweden)
- Accession number :
- edsair.doi.dedup.....b2da500a58c3400f1cab44434ba90541