THE POSSIBLE ROLE OF GENETIC VARIANTS IN PREDICTING ANTRACICLYNE-INDUCED CARDIOTOXICITY

Authors :: Sara Capellini
Ilaria Papa
Savina Nodari
Edda Simoncini
Luca Ambrosiani
Marco Triggiani
Annalisa Pizzuto
Martina Fragni
Sandra Sigala
Vito Amoroso
Graziella Bonetti
Source :: Journal of the American College of Cardiology. 63:A832
Publication Year :: 2014
Publisher :: Elsevier BV, 2014.
Abstract: interpatient variability in anthracycline(ANT)metabolism may contribute to the development of cardiotoxicity(CTX). Aim of the study:to verify the role of genetic variants of enzymes involved in drug metabolism to predict ANT-induced CTX risk in patients(pts)with non metastatic breast Cancer(BC).

Subjects :: Cardiotoxicity
Anthracycline
business.industry
Genetic variants
food and beverages
biochemical phenomena, metabolism, and nutrition
medicine.disease
Breast cancer
medicine
Cancer research
Non metastatic
In patient
Cardiology and Cardiovascular Medicine
business
Drug metabolism

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