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Remarkable Levels of 15N Polarization Delivered through SABRE Into Unlabeled Pyridine, Pyrazine or Metronidazole Enable Single Scan NMR Quantification at the mM Level
- Source :
- The Journal of Physical Chemistry. B
- Publication Year :
- 2020
-
Abstract
- While many drugs and metabolites contain nitrogen, harnessing their diagnostic 15N NMR signature for their characterization is underutilized because of inherent detection difficulties. Here, we demonstrate how precise ultralow field signal amplification by reversible exchange (±0.2 mG) in conjunction parahydrogen and an iridium precatalyst of the form IrCl(COD)(NHC) with the coligand d9-benzylamine allows the naturally abundant 15N NMR signatures of pyridine, pyrazine, metronidazole, and acetonitrile to be readily detected at 9.4 T in single NMR observations through >50% 15N polarization levels. These signals allow for rapid and precise reagent quantification via a response that varies linearly over the 2-70 mM concentration range.
- Subjects :
- 010304 chemical physics
Pyrazine
Analytical chemistry
chemistry.chemical_element
010402 general chemistry
Spin isomers of hydrogen
Polarization (waves)
01 natural sciences
Article
3. Good health
0104 chemical sciences
Surfaces, Coatings and Films
chemistry.chemical_compound
chemistry
Reagent
0103 physical sciences
Pyridine
Materials Chemistry
Iridium
Single scan
Physical and Theoretical Chemistry
Acetonitrile
Subjects
Details
- Language :
- English
- ISSN :
- 15205207
- Database :
- OpenAIRE
- Journal :
- The Journal of Physical Chemistry. B
- Accession number :
- edsair.doi.dedup.....b2c3ec7bc9e1f38061c5257a206564d2