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Sarcoidosis. Disease progression based on radiological and functional course: Predictive factors
- Source :
- Heart & Lung. 56:62-69
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Sarcoidosis is a multiorgan granulomatous disease with a variable course.The purpose of this study is to identify the patients that are more likely to experience disease progression.A retrospective study in patients ≥18 years. Pulmonary function and radiological stage (Scadding criteria) were assessed at diagnosis, and at 1, 3 and 5 years. Sarcoidosis progression was established based on deterioration of radiological or pulmonary function (decrease ≥10% of FVC and/or ≥15% of diffusing capacity of the lung (DLCO).The sample included 277 caucasian patients [mean age, 50±13.6; 69.7% between 31-60 years; 56.3% men]. In total, 65% had stage II sarcoidosis, whereas only 8.3% had stage III/IV disease. Mean pulmonary function (FVC, FEVAt 3 years, a third of patients experienced sarcoidosis progression. Age was the only factor associated with disease prognosis.
Details
- ISSN :
- 01479563
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Heart & Lung
- Accession number :
- edsair.doi.dedup.....b2b31042edf82ea3c06d53c790d1dfe2