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High fat fed hamster, a unique animal model for treatment of diabetic dyslipidemia with peroxisome proliferator activated receptor alpha selective agonists
- Source :
- European journal of pharmacology. 427(3)
- Publication Year :
- 2001
-
Abstract
- Dyslipidemia, a major risk factor for cardiovascular disease, may be directly linked to diabetic hyperglycemia and insulin resistance. An appropriate dyslipidemic animal model that has diabetes would provide an important tool for research on the treatment of diabetic dyslipidemia. Ten days of high fat feeding in golden Syrian hamsters resulted in a significant increase in insulin resistance and baseline serum lipid levels accompanied by a pronounced dyslipidemia. Thirteen days of treatment with fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARalpha) selective agonist, produced a dose-dependent decrease in serum lipid levels. The pattern observed was characterized by lowered very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) and raised high-density lipoprotein (HDL) cholesterol in a fashion similar to that seen in man. Diabetic conditions were also significantly improved by fenofibrate with a normalization of impaired glucose tolerance and an improvement of insulin sensitivity during an oral glucose tolerance test. These data suggest that fenofibrate may correct not only the dyslipidemia but also the insulin resistance caused by a high fat diet, and the high fat fed hamster may be a good animal model for research on the treatment of diabetic dyslipidemia with PPARalpha selective agonists.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Very low-density lipoprotein
Cholesterol, VLDL
Receptors, Cytoplasmic and Nuclear
Hyperlipidemias
Biology
Gene Expression Regulation, Enzymologic
Diabetes Mellitus, Experimental
Impaired glucose tolerance
chemistry.chemical_compound
Insulin resistance
Fenofibrate
Diabetes mellitus
Internal medicine
Cricetinae
medicine
Animals
Insulin
RNA, Messenger
Hypolipidemic Agents
Pharmacology
Dose-Response Relationship, Drug
Mesocricetus
Cholesterol
Fatty Acids
nutritional and metabolic diseases
Cholesterol, LDL
medicine.disease
Dietary Fats
Lipids
Disease Models, Animal
Endocrinology
chemistry
Liver
lipids (amino acids, peptides, and proteins)
Hydroxymethylglutaryl CoA Reductases
Peroxisome proliferator-activated receptor alpha
Oxidation-Reduction
Dyslipidemia
medicine.drug
Transcription Factors
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 427
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....b2b2f0a13e855ca26ff3abe52f144f74