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Case of punctate palmoplantar keratoderma type I treated with combination of low-dose oral acitretin and topical salicylic acid and steroid
- Source :
- The Journal of Dermatology. 45:609-612
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Palmoplantar keratodermas (PPK) are heterogeneous disorders characterized by abnormal keratinization. Especially, punctate PPK (PPPK), one of the subtypes of hereditary PPK, is a rare punctate keratoderma characterized by tiny "raindrop" keratoses having a tendency to coalesce on the edge of soles, which are exposed to sustained pressure. If typical punctate lesions are confined to the palms and soles and the patient has a family history and late onset, it can be considered as PPPK type I (PPKP1), also called Buschke-Fisher-Brauer disease. The exact etiology of PPPK has not been fully understood. Furthermore, no standardized treatment for PPPK has been established and treatment options are limited. Above all, traditional systemic retinoids have been used in several cases, but dose-related adverse effects are common. Therefore, combination of low-dose systemic retinoids and adjuvant topical therapy can be an alternative treatment option for PPPK. Herein, we report a case of PPKP1 treated with combination of low-dose oral acitretin (10 mg/day) and topical salicylic acid and steroid. Despite low capacity, low-dose acitretin showed excellent regression of the lesions by combined use of topical ointments. The supplementary topical therapy may be useful in reducing the dose of systemic retinoids and preventing potential toxicity.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Combination therapy
Biopsy
medicine.medical_treatment
Keratolytic
Dermatology
Acitretin
Ointments
030207 dermatology & venereal diseases
03 medical and health sciences
Keratolytic Agents
0302 clinical medicine
Keratoderma, Palmoplantar
medicine
Humans
Adverse effect
Glucocorticoids
Skin
Dose-Response Relationship, Drug
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
030104 developmental biology
Etiology
Drug Therapy, Combination
Salicylic Acid
business
Adjuvant
Topical steroid
medicine.drug
Subjects
Details
- ISSN :
- 03852407
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- The Journal of Dermatology
- Accession number :
- edsair.doi.dedup.....b2a035001dc1e564b3d720d6afe4acdb