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Tuberculosis infection in HIV vs . non‐HIV patients
- Source :
- HIV Medicine. 22:775-779
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Objectives Tuberculosis (TB) is the most common opportunistic infection and cause of mortality among people living with HIV, and it is possible that it may also influence the evolution of the HIV infection. We assessed the differences between HIV-positive and -negative people infected with TB. Methods The present study is a cross-sectional retrospective study by electronic record revision. We included patients admitted to a tertiary hospital with a diagnosis of TB between 2011 and 2016, comparing those with HIV coinfection with non-HIV patients, according to demographic and clinical characteristics. Results This study included 591 patients, of whom 32% were HIV-coinfected. HIV-TB patients were younger, with a predominance of male gender. Considering TB risk factors, there was a higher prevalence of homelessness and intravenous drug use in the HIV group. In the non-HIV group, direct contact with other patients with TB and immunosuppression were more prevalent. Relative to TB characteristics, the HIV-coinfected group presents with a higher prevalence of disseminated disease and a higher occurrence of previous TB infection. Cancer was the most frequent cause of immunosuppression in the HIV group and the number testing positive for TB via microbiological culture was lower. Assessment of microbiological resistance and in-hospital mortality showed similar numbers in both groups. Conclusions There are few papers comparing clinical course of TB between HIV-infected and non-infected patients. Our study differs from others in the literature as we focused on a country with middling incidence of TB and further characterized the differences between HIV-infected and non-infected patients which can contribute to the management of these patients.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Tuberculosis
Microbiological culture
Opportunistic infection
medicine.medical_treatment
Antitubercular Agents
HIV Infections
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Pharmacology (medical)
Disseminated disease
030212 general & internal medicine
Retrospective Studies
Coinfection
business.industry
Health Policy
Incidence (epidemiology)
virus diseases
Cancer
Immunosuppression
Retrospective cohort study
medicine.disease
030112 virology
Cross-Sectional Studies
Infectious Diseases
Female
business
Subjects
Details
- ISSN :
- 14681293 and 14642662
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- HIV Medicine
- Accession number :
- edsair.doi.dedup.....b29235b62e1a074bd917579b4777f98a
- Full Text :
- https://doi.org/10.1111/hiv.13119