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Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study
- Source :
- Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017), Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- The dietary intake of methyl donors is favorably associated with many diseases, but the findings regarding primary liver cancer (PLC) risk are limited. This study investigated the association between the intake of choline, betaine and methionine and PLC risk in adults. This 1:1 matched case-control study enrolled 644 hospital-based PLC patients and 644 community-based controls who were matched by sex and age, in Guangzhou, China. An interviewer-administered questionnaire and a food-frequency questionnaire were used to collect general information and dietary intake information. Conditional logistic regression showed a significantly inverse association between total choline and betaine intakes and PLC risk. The multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) for PLC for the top (vs. bottom) tertile were 0.34 (0.24–0.49; P -trend P -trend = 0.011) for betaine. No significant association was observed between the intake of methionine and PLC risk (P > 0.05). For individual choline compounds, higher consumptions of free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine and sphingomyelin were associated with a lower PLC risk (all P-trend P-interactions: 0.488–0.890). Our findings suggest that higher choline and betaine intakes may be associated with a lower risk of PLC.
- Subjects :
- Adult
Male
0301 basic medicine
China
medicine.medical_specialty
Adolescent
Science
Lower risk
Risk Assessment
Article
Choline
Young Adult
03 medical and health sciences
chemistry.chemical_compound
Methionine
0302 clinical medicine
Betaine
Risk Factors
Internal medicine
Phosphatidylcholine
Odds Ratio
Humans
Medicine
Aged
Phosphocholine
Aged, 80 and over
Multidisciplinary
business.industry
Liver Neoplasms
Case-control study
Odds ratio
Middle Aged
Diet
030104 developmental biology
Endocrinology
chemistry
Biochemistry
Case-Control Studies
Population Surveillance
030220 oncology & carcinogenesis
Female
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....b277b7cd827d64a0d2772766a4baecca