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Interleukin-6 as inflammatory marker referring to multiple organ dysfunction syndrome in severely injured children
- Source :
- Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
- Publisher :
- Springer Nature
-
Abstract
- Background Despite the suggestion that the inflammatory response in traumatized children is functionally unique, prognostic markers predicting pediatric multiple organ failure are lacking. We intended to verify whether Interleukin-6 (IL-6) displays a pivotal role in pediatric trauma similar to adults. Methods Traumatized children less than 18 years of age with an Injury Severity Score >9 points and consecutive admission to the hospital’s pediatric intensive care unit were included. Organ function was evaluated according to the score by Marshall et al. while IL-6 levels were measured repetitively every morning. Results 59 traumatized children were included (8.4 ± 4.4 years; 57.6% male gender). Incidence of MODS was 11.9%. No differences were found referring to age, gender, injury distribution or overall injury severity between children with and without MODS. Increased IL-6 levels during hospital admission were associated with injury severity (Spearman correlation: r = 0.522, p
- Subjects :
- Male
Pathology
medicine.medical_specialty
Adolescent
Inflammatory response
Multiple Organ Failure
Multiple organ dysfunction syndrome
Bioinformatics
MODS
Critical Care and Intensive Care Medicine
Injury Severity Score
Inflammatory marker
medicine
Humans
Prospective Studies
Interleukin 6
Child
Original Research
Inflammation
IL-6
biology
business.industry
Interleukin-6
Multiple Trauma
Pediatric trauma
medicine.disease
biology.protein
Emergency Medicine
Female
business
Biomarkers
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 17577241
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
- Accession number :
- edsair.doi.dedup.....b27207591b2900e9f4ee95fc2a801b5a
- Full Text :
- https://doi.org/10.1186/1757-7241-22-16