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Tumor vessel depiction with contrast-enhanced endoscopic ultrasonography predicts efficacy of chemotherapy in pancreatic cancer
- Source :
- Pancreas. 42(6)
- Publication Year :
- 2013
-
Abstract
- Contrast-enhanced endoscopic ultrasonography (CE-EUS) is a new imaging modality for pancreatic lesions. The aim of this study was to evaluate if CE-EUS is useful for predicting treatment efficacy before pancreatic cancer chemotherapy by assessing intratumoral vessel flow.Thirty-nine patients with unresectable advanced pancreatic cancer underwent CE-EUS before chemotherapy. The patients were divided into 2 groups according to the intratumoral vessel flow observed with CE-EUS: vessel sign-positive and vessel sign-negative groups. Patient prognosis was investigated according to presence or absence of the vessel sign.Two patients were excluded due to poor visualization of CE-EUS images; therefore, 37 patients were analyzed. Contrast-enhanced EUS revealed positive vessel sign in 20 patients, whereas it revealed negative vessel sign in 17 patients. Both progression-free survival and overall survival were significantly longer in the positive- versus negative vessel sign groups (P = 0.037 and P = 0.027, respectively). Multivariate analysis demonstrated that the positive vessel sign was an independent factor associated with longer overall survival (hazard ratio, 0.22; 95% confidence interval, 0.08-0.53).Evaluation of intratumoral vessel flow by CE-EUS could be useful for predicting efficacy of chemotherapy in patients with pancreatic cancer. Contrast-enhanced EUS could be used before chemotherapy for inoperable pancreatic cancer.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Treatment outcome
Contrast Media
Antineoplastic Agents
Endoscopic ultrasonography
Tumor vessel
Endosonography
Neovascularization
Endocrinology
Pancreatic cancer
Internal Medicine
medicine
Humans
Survival analysis
Aged
Chemotherapy
Hepatology
Neovascularization, Pathologic
business.industry
Middle Aged
medicine.disease
Image Enhancement
Prognosis
Survival Analysis
digestive system diseases
Treatment efficacy
Pancreatic Neoplasms
Treatment Outcome
Multivariate Analysis
Blood Vessels
Female
Radiology
medicine.symptom
business
Blood Flow Velocity
Subjects
Details
- ISSN :
- 15364828
- Volume :
- 42
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....b26c3cd6d23692e0d5e27986f4d82e54