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Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system:Effect of opioids
- Source :
- Mark, E B, Klinge, M W, Grønlund, D, Poulsen, J L, Schlageter, V, Scott, S M, Krogh, K & Drewes, A M 2020, ' Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system : Effect of opioids ', Neurogastroenterology and Motility, vol. 32, no. 3, e13753 . https://doi.org/10.1111/nmo.13753
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: Opioid treatment often causes debilitating constipation. However, it is not well described how opioids affect colonic motility and whether opioid-induced constipation is due to either a decrease of powerful peristaltic contractions or "uncoordinated" peristalsis. The present study aims to investigate the effect of oxycodone on parameters of colonic motility and to determine whether motility is normalized by the opioid antagonist naloxegol.METHODS: In two randomized, double-blind crossover trials, oxycodone or placebo was administered to 25 healthy males (Trial A), while another 24 healthy males were administered oxycodone with naloxegol or placebo (Trial B). Colonic motility was assessed by tracking the progression of an electromagnetic capsule throughout the large intestine. Segmental colonic transit times and capsule movements were calculated using displacement distance and velocity.KEY RESULTS: In Trial A, colonic transit time increased during oxycodone treatment compared with placebo (39 vs 18 hours, P < .01). Displacement during long fast antegrade movements was shorter during oxycodone treatment than with placebo (10 vs 20 cm, P = .03). In Trial B, colonic transit time was faster during oxycodone + naloxegol than during oxycodone + placebo (40 vs 55 hours, P = .049), mainly caused by an increase of the percentwise fraction of distance covered by fast movements in the left colon (P = .001).CONCLUSION & INFERENCES: Oxycodone treatment impaired colonic motility, manifested as increased transit time, specifically decreased long fast antegrade movements, and addition of naloxegol improved motility dynamics. In humans, the increased transit time during opioid treatment is caused by a decrease in long fast movements rather than uncoordinated peristalsis.
- Subjects :
- Adult
Male
Constipation
Physiology
medicine.drug_class
Narcotic Antagonists
PATHOPHYSIOLOGY
Monitoring, Ambulatory
Motility
CONSTIPATION
Placebo
Capsule Endoscopy
MORPHINE
Polyethylene Glycols
Young Adult
Naloxegol
chemistry.chemical_compound
Double-Blind Method
opioid antagonists
MANAGEMENT
medicine
Humans
Gastrointestinal Transit
Peristalsis
Cross-Over Studies
INDUCED BOWEL DYSFUNCTION
colon
Endocrine and Autonomic Systems
business.industry
Gastroenterology
opioids
Middle Aged
Analgesics, Opioid
INSIGHTS
Morphinans
chemistry
Opioid
motility
Anesthesia
electromagnetic capsule
REGIONAL GASTROINTESTINAL TRANSIT
Female
medicine.symptom
Gastrointestinal Motility
business
Oxycodone
Opioid antagonist
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Mark, E B, Klinge, M W, Grønlund, D, Poulsen, J L, Schlageter, V, Scott, S M, Krogh, K & Drewes, A M 2020, ' Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system : Effect of opioids ', Neurogastroenterology and Motility, vol. 32, no. 3, e13753 . https://doi.org/10.1111/nmo.13753
- Accession number :
- edsair.doi.dedup.....b2662c515aa374808b93e9cfa6fb04b2