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Differentially expressed genes in human peripheral blood as potential markers for statin response
- Source :
- Journal of molecular medicine (Berlin, Germany). 90(2)
- Publication Year :
- 2011
-
Abstract
- There is a considerable inter-individual variation in response to statin therapy and one third of patients do not meet their treatment goals. We aimed to identify differentially expressed genes that might be involved in the effects of statin treatment and to suggest potential markers to guide statin therapy. Forty-six healthy Korean subjects received atorvastatin; their whole-genome expression profiles in peripheral blood were analyzed before and after atorvastatin administration in relation with changes in lipid profiles. The expression patterns of the differentially expressed genes were also compared with the data of familial hypercholesterolemia (FH) patients and controls. Pairwise comparison analyses revealed differentially expressed genes involved in diverse biological processes and molecular functions related with immune responses. Atorvastain mainly affected antigen binding, immune or inflammatory response including interleukin pathways. Similar expression patterns of the genes were observed in patients with FH and controls. The Charcol–Leyden crystal (CLC), CCR2, CX3CR1, LRRN3, FOS, LDLR, HLA-DRB1, ERMN, and TCN1 genes were significantly associated with cholesterol levels or statin response. Interestingly, the CLC gene, which was significantly altered by atorvastatin administration and differentially expressed between FH patients and controls, showed much bigger change in high-responsive group than in low-responsive group. We identified differentially expressed genes that might be involved in mechanisms underlying the known pleiotropic effects of atorvastatin, baseline cholesterol levels, and drug response. Our findings suggest CLC as a new candidate marker for statin response, and further validation is needed.
- Subjects :
- Adult
Male
Statin
medicine.drug_class
Atorvastatin
Genes, MHC Class II
Hypercholesterolemia
Gene Expression
Familial hypercholesterolemia
Pharmacology
Biomarkers, Pharmacological
Drug Discovery
Gene expression
medicine
Humans
Pyrroles
Genetics (clinical)
biology
Genome, Human
Gene Expression Profiling
nutritional and metabolic diseases
Interleukin
medicine.disease
Molecular medicine
Cholesterol
Heptanoic Acids
Pharmacogenomics
HMG-CoA reductase
biology.protein
Molecular Medicine
lipids (amino acids, peptides, and proteins)
medicine.drug
Subjects
Details
- ISSN :
- 14321440
- Volume :
- 90
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of molecular medicine (Berlin, Germany)
- Accession number :
- edsair.doi.dedup.....b26606cc9cf610ce6d8bc5a95b997166