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Nelfinavir and nevirapine side effects during pregnancy
- Source :
- AIDS (London, England), 19(8), 795-799. Lippincott Williams and Wilkins, AIDS, 19(8), 795-799. Lippincott Williams & Wilkins
- Publication Year :
- 2005
-
Abstract
- Background: The risk of vertical transmission of HIV has been substantially reduced since the introduction of highly active antiretroviral therapy (HAART); however, the impact of taking HAART during pregnancy on the woman, the fetus and the infant is not yet understood. Objective: To assess and compare tolerability, safety and efficacy of nelfinavir- or nevirapine-containing HAART in a cohort of pregnant and non-pregnant HIV-infected women in the Netherlands. Design: Retrospective comparative study. Methods: In 15 centres specializing in HIV in the Netherlands, data on patient characteristics, HAART, adverse events, viral load response, mode of delivery and HIV status of the neonate were obtained from medical records of HIV-infected pregnant women who received HAART during pregnancy between January 1997 and June 2003. These data were compared with a control group of HIV-infected non-pregnant women that was obtained from the Dutch HIV-monitoring foundation database. Results: Data from 186 pregnant and 186 non-pregnant HIV-infected women using a nelfinavir- or nevirapine-containing regimen were analysed. The pregnant women were younger, used a nelfinavir containing regimen more often, had higher CD4 cell counts and lower HIV RNA levels. Nelfinavir-related gastrointestinal symptoms (P
- Subjects :
- Adult
Pediatrics
medicine.medical_specialty
Nevirapine
Immunology
HIV Infections
Acquired immunodeficiency syndrome (AIDS)
Pregnancy
immune system diseases
Antiretroviral Therapy, Highly Active
medicine
Immunology and Allergy
Humans
Pregnancy Complications, Infectious
Adverse effect
Netherlands
Nelfinavir
business.industry
virus diseases
Nausea
HIV Protease Inhibitors
medicine.disease
Surgery
CD4 Lymphocyte Count
Regimen
Infectious Diseases
Tolerability
Anti-Retroviral Agents
Case-Control Studies
Hyperglycemia
Reverse Transcriptase Inhibitors
Female
Chemical and Drug Induced Liver Injury
business
Viral load
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 02699370
- Volume :
- 19
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- AIDS (London, England)
- Accession number :
- edsair.doi.dedup.....b25a98b0f8b8ec85ba924777151dd26b