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Intraluminal plugs in idiopathic and secondary organizing pneumonia: repair or remodelling?
- Source :
- Histopathology. 51:622-630
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Aims: Organizing pneumonia (OP) is an inflammatory lung disease characterized histologically by intraluminal plugs involving alveolar ducts and alveoli. The aim was to examine extracellular matrix repair and remodelling in 12 cases of idiopathic OP and compare these with 11 cases of secondary OP. Methods and results: Collagen/elastic fibre density, myofibroblast proliferation, microvascular density and endothelial activity in the intraluminal plugs were evaluated by histochemistry, immunohistochemistry and morphometry. The density of the collagen system fibres was greater in plugs of idiopathic OP when compared with secondary OP (P
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Histology
Endothelium
CD34
Vascular Cell Adhesion Molecule-1
Antigens, CD34
Vascular permeability
Pathology and Forensic Medicine
Capillary Permeability
Extracellular matrix
Neovascularization
medicine
Humans
Aged
business.industry
Respiratory disease
Microvascular Density
Pneumonia
General Medicine
Middle Aged
Elastic Tissue
medicine.disease
Immunohistochemistry
Pulmonary Alveoli
medicine.anatomical_structure
Female
Collagen
Endothelium, Vascular
medicine.symptom
business
Myofibroblast
Subjects
Details
- ISSN :
- 13652559 and 03090167
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Histopathology
- Accession number :
- edsair.doi.dedup.....b2581a29d350aa3b661458537689f476