Evaluation of matrix metalloproteinases -2 and -9 in cats under bone demineralization secondary to induced thyrotoxicosis

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:56:08Z No. of bitstreams: 1 S0102-09352008000500003.pdf: 257919 bytes, checksum: d1422a2702180a82a41cc6fea3d62ec7 (MD5) Made available in DSpace on 2013-08-22T18:56:08Z (GMT). No. of bitstreams: 1 S0102-09352008000500003.pdf: 257919 bytes, checksum: d1422a2702180a82a41cc6fea3d62ec7 (MD5) Previous issue date: 2008-10-01 Made available in DSpace on 2013-09-30T19:49:44Z (GMT). No. of bitstreams: 2 S0102-09352008000500003.pdf: 257919 bytes, checksum: d1422a2702180a82a41cc6fea3d62ec7 (MD5) S0102-09352008000500003.pdf.txt: 24850 bytes, checksum: 1f0cdee8662fba360312abb716584dc9 (MD5) Previous issue date: 2008-10-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:13:06Z No. of bitstreams: 2 S0102-09352008000500003.pdf: 257919 bytes, checksum: d1422a2702180a82a41cc6fea3d62ec7 (MD5) S0102-09352008000500003.pdf.txt: 24850 bytes, checksum: 1f0cdee8662fba360312abb716584dc9 (MD5) Made available in DSpace on 2014-05-20T15:13:06Z (GMT). No. of bitstreams: 2 S0102-09352008000500003.pdf: 257919 bytes, checksum: d1422a2702180a82a41cc6fea3d62ec7 (MD5) S0102-09352008000500003.pdf.txt: 24850 bytes, checksum: 1f0cdee8662fba360312abb716584dc9 (MD5) Previous issue date: 2008-10-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Observou-se significativo aumento de atividade das formas ativas das metaloproteinases -2 e -9 em gatos com tirotoxicose induzida e desmineralização óssea. As formas pró e intermediária da metaloproteinase -2 elevaram-se com 14 dias de administração hormonal, porém, posteriormente, houve uma tendência de queda. Observou-se correlação negativa entre a forma ativa das metaloproteinases de matriz -2 e -9 e a densidade mineral óssea da extremidade distal do rádio. Os resultados sugerem aumento da degradação da matriz colágena secundária com a elevação dos hormônios tiroidianos. Significant increase of activity of active forms of matrix metalloproteinases -2 and -9 in cats under induced thyrotoxicosis and bone demineralization was observed. Pro and intermediated forms of matrix metalloproteinases -2 and -9 increased at 14 days of hormonal treatment, followed by decrease tendency. A negative correlation between active forms of matrix metalloproteinases -2 and -9 and bone mineral density of radius distal extremity was also observed. The results suggest an increase of collagen matrix degradation secondary to high levels of thyroid hormones. Universidade Federal do Espírito Santo (UFES) Departamento de Medicina Veterinária UNESPAR FFALM UNESP, Fac Med Vet & Zootecnia, Botucatu, SP, Brazil UNICAMP Instituto de Biologia UNESP Inst Biociencias, Botucatu, SP, Brazil UNESP, Fac Med Vet & Zootecnia, Botucatu, SP, Brazil UNESP Inst Biociencias, Botucatu, SP, Brazil