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Endocrine treatment options for advanced breast cancer--the role of fulvestrant
- Source :
- European Journal of Cancer, 41, 3, pp. 346-56, European Journal of Cancer, 41, 346-56
- Publication Year :
- 2005
-
Abstract
- Item does not contain fulltext For many years, tamoxifen has been the 'gold standard' amongst anti-oestrogen therapies for breast cancer. However, the selective aromatase inhibitors (AIs), anastrozole, letrozole and exemestane, have demonstrated advantages over tamoxifen as first-line treatments for advanced disease. Anastrozole is also more effective as an adjuvant treatment in early, operable breast cancer and is being increasingly used in the adjuvant setting. Generally, the selective oestrogen receptor modulators (SERMs), such as toremifene, droloxifene, idoxifene, raloxifene, and arzoxifene, show minimal activity in tamoxifen-resistant disease and show no superiority over tamoxifen as first-line treatments. In addition to these agents, other treatment options for advanced disease include high-dose oestrogens and progestins. Response rates for high-dose oestrogens and tamoxifen are similar, but the use of oestrogens is limited by their toxicity profile. Consequently, there is a need for new endocrine treatment options for breast cancer, particularly for use in disease that is resistant to tamoxifen or AIs. Fulvestrant ('Faslodex') is a new type of steroidal oestrogen receptor (ER) antagonist that downregulates cellular levels of the ER and progesterone receptor and has no agonist activity. This paper reviews the key efficacy and tolerability data for fulvestrant in postmenopausal women in the context of other endocrine therapies and explores the potential role of fulvestrant within the sequencing of endocrine therapies for advanced breast cancer.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Antineoplastic Agents, Hormonal
Anastrozole
Breast Neoplasms
Pharmacology
Arzoxifene
chemistry.chemical_compound
Breast cancer
Exemestane
Interventional oncology [UMCN 1.5]
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Nitriles
medicine
Humans
Raloxifene
skin and connective tissue diseases
Fulvestrant
Estradiol
business.industry
Estrogen Antagonists
Gefitinib
Triazoles
medicine.disease
Antiestrogen
Androstadienes
Postmenopause
Tamoxifen
Treatment Outcome
chemistry
Quinazolines
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 09598049
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer, 41, 3, pp. 346-56, European Journal of Cancer, 41, 346-56
- Accession number :
- edsair.doi.dedup.....b24f10fd0244e0161f7113e01cdb2ad0